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Because -glutamyl transpeptidase is a plasma membrane-bound enzyme with its active site on the extracellular surface of the membrane, export of GSH and its adducts into the extracellular space is the initial, and presumably regulated step in their turnover in all mammalian cells

Vitamin B12 (cyanocobalamin) is unique it is the only one that contains the mineral cobalt

Vitamin B12 is essential for the production of red blood cells, the proper functioning of the nervous system, and the synthesis of DNA

Low vitamin B12 levels can potentiate methotrexate-induced neurotoxicity [149]

thus, the inhibition of pyruvate via gliotoxin can induce apoptosis in the human gloma cell line U87, synergize with temozolomide