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For example, acetate can reduce appetite via a central homeostatic mechanism by crossing the blood-brain barrier (Kimura et al., 2013)

doi: 10.1165/rcmb.2018-0335OC, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 78.ODonnell J, Finer NN, Rich W, Barshop BA, Barrington KJ
