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To further validate the role of the endogenous carnitine shuttle to the observed histone acetylation, we knocked down carnitine O -acetyltransferase (CrAT) and carnitine O -octanoyltransferase (CrOT) (Extended Data Fig

It was designed as an analogue of alpha-melanocyte-stimulating hormone (alpha-MSH) with a cyclic structure that gives it greater metabolic stability

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There was a lack of improvement in power or time to exhaustion during a test at 85% O 2 on a cycle ergometer or in the speed achieved at 4 mmol/lactate in tests of submaximal performance after a marathon race [24]

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