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Moreover, forced expression of constitutive-active -catenin or genetic ablation of Tcf/ -catenin transcriptional activity in tumor cells of Rip1Tag2 transgenic mice does not affect tumor progression

Studies have identified SREBP2 as a novel substrate of USP28, a deubiquitinase frequently upregulated in lung cancer

J Lipid Res 35(9):15111523 Berbee JF, van der Hoogt CC, Sundararaman D, Havekes LM, Rensen PC (2005) Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

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Amphipathic helices are protein segments arranged in coils so that the hydrophobic amino acid residues interact with lipids, whereas the part of the helix containing hydrophilic amino acids faces away from the lipids and toward the aqueous environment