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NAD + metabolism is a basis of epigenetic regulatory metabolic reprogramming (91)
The Food and Nutrition Board, the National Academy of Sciences-National Research Council recommend that lactating women should consume 4 mcg of vitamin B12 daily (11)

The USDA Agricultural Research Service used the 148 pmol/L threshold in their national prevalence studies, and the NIH Office of Dietary Supplements acknowledges that lab reference ranges can vary between institutions

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Still, its not clear whether B12 supplementation can reduce the risk of heart disease directly (13)