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There is also evidence that these drugs are effective for DPN (136, 137)

The twenty-two chapters explore such topics as: Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses Biological activities of GSH and sulfur amino acids and their role in modulating cell processes Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models

[Abstract]2025 Feb;39(2):581-592

Key for these questions are the proteomic approaches aiming to identify nuclear PTM occurring on redox-sensitive residues, and the structure biology techniques designed to visualize redox-based modifications on protein structure (Waszczak et al., 2014

S1pr3 inhibitors such as CAY10444 and TY52156 demonstrate therapeutic promise (181)

Figure 1 illustrates the principal findings related to SCOPA