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Vitamin B12 is an important nutrient, and deficiencies often result from poor absorption or insufficient dietary intake or previous operations

Normal serum vitamin B12 levels range between 200-900 pg/mL, with concentrations less than 200 pg/mL usually resulting in deficiency

Much of the debate surrounding folic acid, methylfolate and MTHFR variants centres on their effects on these metabolic pathways and, consequently, on homocysteine concentrations