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glutathione protects cancer cells Tumor-targeted oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma Utilizing glutathione-triggered nanoparticles to enhance
Description
The high expression of HIF-1 and HIF-2 increases the expression levels of downstream target genes VEGF and VEGF receptors, induces the release of Angiopoietin-2 from the Weibel-Palade body in vascular endothelial cells, and promotes angiogenesis (39, 40)

As noted above, p53 acts as a direct trigger of cell death via its different targets (PUMA-, NOXA, PIDD)

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations

doi: 10.1038/s41598-022-10051-z 3 Rodriguez-SanchezIRodriguez-MaasLLaosaO

Biomaterials 30 (29), 52925304

Timing: 30 min
