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The first one is enzymatic defense, and the second is low molecular weight antioxidants such as vitamins and phytochemicals

Drug-induced GR inhibition : Several medications, including antimalarials, antipsychotics, and certain chemotherapeutic agents, can inhibit GR activity

Non-enzymatic antioxidants include both lipid-soluble (-tocopherol and -carotene) and water-soluble (glutathione, ascorbate, etc.) antioxidants

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- The shaft is usually flexible enough to reach different parts of the oral cavity easily, yet sturdy enough to maintain its shape during the sampling process