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doi: 10.1002/ptr.8122 Summary Keywords sulforaphane, glucosinolate, cruciferous, neurodevelopmental, neurodegenerative, neuroinflammation Citation Ramakrishnan M, Fahey JW, Zimmerman AW, Zhou X and Panjwani AA (2024) The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
During synaptic activity, astrocytes rapidly clear synaptic glutamate via Na + -dependent transporters (GLT-1/GLAST), activating the Na + /K + -ATPase which establishes a Na + gradient driving GLUT1/3-mediated glucose uptake
Accordingly, glutathione, its precursors, and/or metabolites serve as biomarkers of disease risk, therapeutic targets, and measures of treatment response

Journal of Medicinal Chemistry, Aug 12, 2021
