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Description
According to Elolimy et al
However, while the G12D, G12V and G12C direct 13 C-glucose carbon flux towards glutamine synthesis, the G12A mutant maintains a higher flux through the TCA cycle and high glutamate levels
However, it is essential to understand that retatrutide has not yet received regulatory approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)
doi: 10.1098/rsob.120144
Mancino and Lawrence, 2010
EMBO J 16:252259
