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That is a meaningful standalone number for a compound that most people only ever discuss as an add-on

2.4 Multiple sclerosis (MS) Gut dysbiosis is seen in MS patients as marked by decreased microbial diversity and shifts among specific taxa, like increased Akkermansia and reduced SCFA-producers (Jangi et al., 2016)

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In the last few months, an important breakthrough has been made with the crystal structures of MOR (Manglik et al., 2012), DOR (Granier et al., 2012), and KOR (Wu et al., 2012) at high resolution

Taken together, these findings suggest that acute sleep deprivation and associated circadian misalignment represents a different physiological challenge than chronic circadian misalignment