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The first reaction is rate limiting and is catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

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Biological samples collection Samples collected from five apparently healthy anonymous individuals were studied

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Also constant improvements in instrumentation and software are improving DDA performances and the development of all-ion fragmentation in data-independent acquisition (Bruderer et al., 2015) will certainly be viable avenues for future applications of HRMS in protein binding studies

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