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We used a Mendelian randomization design to test whether this relation might be causal

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It's possible that AOD9604 may influence the fat cells and lipolytic receptors, particularly given its observed association with changes in weight and fat in murine models

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Step 3 Downstream signaling: In animal models, GHSR-1a activation is associated with pulsatile GH release from the anterior pituitary, mirroring endogenous GH pulse architecture

GSTs may also bind toxins and function as transport proteins, which gave rise to the early term for GSTs, ligandin