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For example, dietary supplementation of polyphenol-rich extracts in animal models, such as grape seed extract in broiler chickens and pigs, has been shown to increase the concentration of antioxidant markers like vitamin E in plasma and tissues, suggesting not only the bioavailability but also the effective physiological action of polyphenols after digestion (363)

Iron chelators (e.g., deferoxamine) are also under investigation to determine their potential role in reducing iron-driven oxidative stress, offering a promising avenue for psoriasis treatment (191, 195197)

Mozsolits, H., Lee, T., Wirth, H., Perlmutter, P

By inhibiting GLS, downstream production of glutamate and, subsequently, -KG should be decreased

Evidence integration judgments were developed through a comprehensive review of epidemiologic and animal toxicological evidence, with consideration of various factors, such as the relevance of animal toxicological findings to human health, data consistency within and across evidence streams, sensitivity to susceptible populations, biological plausibility and mode of action, and mechanistic evidence to aid in determining biological plausibility

[DOI] [PubMed] [Google Scholar] 42.Claria J, Serhan CN