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Wang H, Huang M, Wang W, Zhang Y, Ma X, Luo L et al (2021) Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance

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Histological analysis further confirmed the protective effects of NAC, while the combined treatment with NAC and tadalafil provided additional benefits

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