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Description
The variants with single Pen mutations folded efficiently and retained the desired secondary structure
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SG: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review & editing
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10.1016/j.isci.2022.105013 114 VinogradovaM.GehlingV
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these findings indicate the antiapoptotic potential of SA, leading to enhanced cell survival
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PMID: 36430869 Int J Mol Sci Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia
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The above calculation is obviously simplistic as the rates of the two reactions will vary as a function of changes in substrate concentrations following the onset of stress, and kinetic modeling would be required to examine the question more closely
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