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Secondly, the persistently high level of LH secretion promotes ovarian stromal vascular proliferation, increased stromal blood flow, enhanced oxygen metabolism, and increased production of reactive oxygen species (ROS), triggering oxidative stress, which adversely affects oocyte maturation, fertilization, embryo development, and the progress of pregnancy (Li et al., 2022)

By increasing glutathione levels, NAC helps protect and repair the intestinal lining, calm oxidative stress within the gut, and support intestinal permeability (leaky gut)

doi: 10.1007/s11064-022-03770-2

[DOI] [PubMed] [Google Scholar] Surai P.F, Kochish I.I, Fisinin V.I, Kidd M.T

Berghoff, [email protected] This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Mechanistically, low CFTR expression impairs the expression of the chloride ion-sensitive with-no-lysine kinase 1 (WNK1) protein, thereby leading to activation of transient receptor potential cation vanilloid 4 (TRPV4)