inhibitor glutathione peroxidase The Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity GPX1 (Glutathione Peroxidase, GSHPx) Gene

Additionally, Nrf2 overactivation in hepatoma cells inhibits the pro-inflammatory response by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, creating a favorable environment for malignant cell survival and protecting them from oxidative stress [138]

PMID: 22921233

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