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Single-cell RNA sequencing (scRNA-seq) demonstrated ACE2 receptor expression was primarily restricted to lung pneumocytes, gut absorptive enterocytes, and nasal mucosa goblet secretory cells [24]

The co-activator YAP, which promotes melanoma growth and spread, controls the Arp2/3 subunit ARPC5

Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

The standard method for direct estimation of the brain delivery extent (K p,uu,brain ) is a cerebral microdialysis technique, which is used for continuous monitoring of unbound concentrations of the drug in the brain ISF and blood over the time via inserted probes into the brain parenchyma (90)

12, 4th ed

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