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However, there is now a substantial literature of genetic association studies of UA-related genes and PD

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Lipid peroxidation is central to membrane disruption: oxidation of polyunsaturated fatty acids (e.g., arachidonic acid, docosahexaenoic acid) generates lipid peroxides (e.g., 4-HNE), which crosslink with amino groups of membrane phospholipids, destabilizing the lipid bilayer and increasing permeability

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The researchers then treated these aged human neurons with the Pinealon (EDR) peptide