glutathione cream vs pills 9 Health Benefits of Glutathione Whitening Pills - Skin

In support with this, several studies highlighted that cells experiencing hypoxia or mitochondrial dysfunction have decreased glutamine oxidation and rely on carbon sources, other than glucose and glutamine, to supply metabolic intermediates under hypoxic conditions 46,47,48

IV glutathione has a much higher bioavailability than oral or sublingual forms as it bypasses the stomach, meaning it boosts levels much more efficiently

Agsin in their guidelines

4 Skin Thickness and Hydration A pilot study on topical copper tripeptide complexes confirmed increases in both epidermal and dermal thickness, improved hydration, visible smoothing from stimulated collagen synthesis, and increased skin elasticity

It has been reported that plasma membranes have specific binding sites of GSH which have an interaction with the glutamate binding sites [24]

doi: 10.1038/npp.2014.326