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Based on these observations, ebselen was concluded to be the GPx mimic

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It has been found that micronutrient imbalances are present in patients with schizophrenia (38)

The literature further indicates that the simultaneous intake of acidsuppressing medications (such as proton pump inhibitors [PPIs] and histamine 2 receptor antagonists [H2RAs]) with metformin increases the risk of vitamin B12 deficiency in individuals with T2D [44-48]

Although the good selectivity and inhibitory effect of this type compound, 125-127 did not display satisfactory pharmacokinetic property