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Additionally, hormonal variations, particularly fluctuations in estrogen levels, have been shown to affect ligament laxity and strength, further contributing to the higher incidence of ACL injuries in females

As I looked at epigenetics, it really compelled me to pause

10.1093/ijnp/pyy008 [DOI] [PMC free article] [PubMed] [Google Scholar] 90.Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, et al

Their importance to both pharmacokinetic exposure (ADME) and pharmacodynamic response (effect on target and off-targets) have been thoroughly studied and described in the literature (Figure 1)

De Miranda, B

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