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We added in Anise seed (Pimpinella anisum) because it has a long history as a galactagogue herb, traditionally used to support breast milk production

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So I know you touched a little bit about stress just now, but yeah, I mean that quote says a lot

It was found that berberine reduced the expression of toll-like receptor 4 (TLR4), Src family tyrosine kinase (LYN), phatidylinositol 3-kinase (PI3K), NF-B, TNF- , IL-1, and caspase-3, which was accompanied by a reduction in cell apoptosis, which pointed to the potential significance of berberine in the therapy of PCOS (123)

These approvals came following data from a phase III trial in both adults and children aged 12+ with severe SCD or TDT