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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

Nature Chemical Biology 9(5):300-306

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Autoimmune Inflammation Emerging research in conditions like Graves' orbitopathy shows that 5-Amino-1MQ can significantly reduce the production of pro-inflammatory cytokines (IL-6, IL-8) and suppress pathogenic tissue remodeling

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771

A., et al
