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Effector Treg cells take up lactate through MCT1 to enhance PD-1 expression and remodel its function and phenotype, which may be one of the reasons for resistance to PD-1 immunotherapy [16]

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In a further study this group [28] showed that L-carnitine treatment significantly attenuated the radiation-induced morphological changes and germ cell apoptosis in the irradiated rat testis

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