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Further analysis revealed that concomitant MACC1 (MET transcriptional activator) upregulation and miR-1 downregulation are required to elicit the highest level of MET expression

Optimal results appear with 8-12 weeks of consistent use

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Funding This work was supported by Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai

Common sources of exosomes include: MSC-derived exosomes PRP-exosome hybrids Adipose exosomes Platelet-derived extracellular vesicles (P-EVs) The following chart shows the efficacy of various exosomes for pain reduction and cartilage regeneration: BMAC and MFAT BMAC (Bone Marrow Aspirate Concentrate) and MFAT (Micro-Fragmented Adipose Tissue) are orthobiologics rich in mesenchymal stem cells (MSCs), growth factors, and anti-inflammatory mediators