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The ability of G/D-CuP to scavenge ROS was evaluated using a ROS fluorescent probe (DCFH-DA)

This results in oxidative stress which hinders not only the production of thyroid hormones, but also the conversion of T4 into the active T3 form used by cells

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Excess generation of reactive oxygen species (ROS) in the form of superoxide anions, hydrogen peroxide, and hydroxyl radicals can cause extensive damage to cellular macromolecules

This does not mean you must give up coffee entirely, but it does suggest that moderation is vital for those prioritising their antioxidant status

The peptide enhances TGF-beta receptor expression and increases cellular responsiveness to TGF-beta ligands, amplifying SMAD2/3 phosphorylation and nuclear translocation