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The problem with carnitine Muscle takes up carnitine against a very large (about 1,000-fold) concentration gradient (plasma carnitine is 40-60 mol/L and muscle carnitine is 4-5 mmol/L)

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alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation

This mechanism may be related to both lysosomal dysfunction and redox regulation (Boini et al., 2017)

Prasanta Basak, Ashutossh Naaraayan, Abhishek Nimkar, Amrah Hasan, Sushil Pant, Momcilo Durdevic, Henrik Elenius, Corina, Nava Suarez, Kameswari Lakshmi, Michael Mandel, Stephen Jesmajian

Using FlyAtlas to identify better Drosophila melanogaster models of human disease