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Vitamin D supplementation can help prevent a vitamin D deficiency (154)

This finding suggests that LC may have a vasodilatory effect, contributing to a more efficient cardiovascular response

However, XO-derived RS production is increased in tissues affected by certain diseases, including atherosclerosis (Nasi et al., 2021), rheumatoid arthritis (Hanachi et al., 2009), or Dupuytrens contracture (Murrell and Hooper, 1992)

129.Gelbard M, Lipshultz LI, Tursi J, Smith T, Kaufman G, Levine LA

These diseases include chronic obstructive pulmonary disease (COPD), bronchial asthma, acute lung injury (ALI), chronic granulomatous disease (CGD), nonalcoholic fatty liver disease (NAFLD), hepatic ischemiareperfusion (IR) injury, kidney fibrosis, acute kidney injury (AKI), cardiovascular disorders, and cancer (Figure 2

This leads to the last reaction in -oxidation, in which 3-ketoacyl-CoA is thiolytically cleaved to produce acetyl-CoA and the acyl-CoA chain that is two carbons shorter (224)