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One key strategy for targeting nanoparticles (NPs) to specific brain regions is by exploiting the alterations in the neurovascular units and the resulting changes in the local microenvironment associated with specific CNS disorders (72)

Crossing the blood-brain barrier: glutathione-conjugated poly(ethylene imine) for gene delivery

doi: 10.3390/molecules26020288

Lack of specific preclinical disease models The in vitro BBB models, as well as disease models that exist today, are poorly predictive tools

Artif Cells Nanomedicine Biotechnol

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