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It results in an increased risk of fractures

Office of Dietary Supplements NIoH

It is not a stimulant like caffeine, but if you are sensitive to supplements, you may prefer morning or midday doses so your sleep pattern remains undisturbed
Numerous later studies have shown the association between increased plasma TMAO levels with a higher risk of cardiovascular events [63,64,65,66]

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Although vitamin C and caffeine found in some supplements can be mild diuretics, increases in urination frequency are more likely related to increased water consumption
