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Semi-saturation mutagenesis on the conformationally flexible H241 residue shows that only H241N and H241Q retained low activity, indicating that H241 is vital for the conformation required to bind PLP and tyrosine

EPCAM and RAS/MAPK It has been discovered that synergistic activation of this pathway by several factors (such as FGF, SCF, or HGF) stimulates the activation of the MAPK pathway [117]

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Rybak, L

Genetics may affect the activity of enzymes involved in absorption, binding to B 12 blood transport or intracellular proteins and/or B 12 metabolism

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