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2018 doi: 10.1158/0008-5472.CAN-18-1680

Research Evidence Evidence shape FOXO4-DRI has no human clinical evidence: zero published human studies and zero registered trials, completed, ongoing, or terminated

Based on the current level of evidence, other authors have also suggested the use of oral or topical glutathione as an adjunctive therapy for facial melanosis

doi: 10.3390/ijms241713619

The participants were evaluated at the moment of study inclusion (T0) and after eight weeks (T8)