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[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Magana M., Pushpanathan M., Santos A.L., Leanse L., Fernandez M., Ioannidis A., Giulianotti M.A., Apidianakis Y., Bradfute S., Ferguson A.L

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Activation of mTOR in senescent cells contributes to cellular dysfunction and the pro-inflammatory SASP.134 Inhibition of mTOR has been shown to reduce the expression of SASP factors and improve tissue function in animal models of aging.135 Modulation of the SASP: Senescent cells secrete a variety of pro-inflammatory cytokines, chemokines, growth factors, and proteases collectively known as the SASP