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Pancreatic polypeptide and related peptides

For example, during inflammation cytokines like IL-1, IL-6 and TNF increase the translation of the mRNA of HIF-1 in a NF-B dependent way, through the activation of the PI3K/AKT/mTOR pathway (102, 108)

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It is formed by two sulfur atoms linked through a disulfide bond, which remains stable under physiological conditions but enables precise drug release via disulfide linker cleavage in highly reductive environments such as tumor cells