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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

Oxidative stress an imbalance between free radicals and antioxidants that damages DNA, accelerates aging and increases disease risk

Salau AK, Yakubu MT, Oluleye DS, Oloyede OB, Akanji MA (2012) Toxicological evaluation of aqueous leaf extract of Ficus exasperata on selected tissues of normal Wistar rats

[3] Research suggests these findings might indicate selective adipose tissue activity that mechanistically diverges from that of intact hGH, which is believed to produce insulin resistance in preclinical models at comparable biological concentrations

de Koning, H