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J Am Chem Soc, 2014, 136: 35793588 Li M, Wu X, Wang Y, et al

To address these barriers, advanced drug delivery systems (e.g., nanoformulations, liposomal carriers, prodrugs) are being explored to enhance bioavailability and targeted drug delivery to the brain

doi:10.1016/j.yfrne.2011.07.002

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For instance, A oligomers bind CD36/TLR4/TLR6 receptor complexes to activate MyD88-dependent signaling, driving nuclear translocation of NF-B and interferon regulatory factors, thereby initiating transcription of pro-inflammatory cytokines (e.g., IL-1, TNF-) and chemokines [e.g., C-C motif chemokine ligand (CCL)2, CXCL10] (29,30)

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