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It is possible that HLA-B27 may predispose to AS via more than one mechanism, or by different mechanisms in different patients, based on additional genetic, epigenetic and environmental factors

J Clin Invest 134(2):e166134, 2024

Therefore, treatment should follow assessment and structured dosing

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Upon HG exposure, a decreased expression of key proteins associated with mitochondrial biogenesis (CLUH, TOMM70, TIMM13, LONP1, and YME1L1) and those associated with the regulation of mitochondrial DNA (TFAM and LONP1) were verified