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Therefore, additional polar interactions with sulfated ligand-mediated by R197 ECL2 significantly enhance the affinity and potency, providing an explanation for the observation that CCK1R prefers sulfated CCK while CCK2R binds to the sulfated and non-sulfated ligands equally well

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AMP-activated protein kinase Accumulating evidence of AMP-activated protein kinase (AMPK), the master regulator of cellular energy, has been extensively reported in modulating TJs

10.3389/fmolb.2022.925700 58 ZhaoY.LuanH.JiangH.XuY.WuX.ZhangY.et al (2021)

Musculoskeletal effects are typically measured at 2-4 week intervals, with significant differences versus controls appearing by week 3-4

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