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Perez notes

RNS are present in high levels due to the action of the i-NOS enzyme, produced locally due to inflammation

BMJ Case Rep doi:10.1136/bcr-2015-210727 Kim H, Chu K, Jung KH, Lee ST, Kim JM, Lee SK (2012) Acquired encephalopathy associated with carnitine deficiency after cefditoren pivoxil administration

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Furthermore, the neurotransmission decrease conducts to an excess of neuroinhibition, which contributes to encephalopathy