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Funding This work was supported by Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (No.202201 AY070001 - 066), Funding of the"famous doctors"project of the support plan for the talents of Xingdian (No.RLMY20220005), The scientific and technological innovation team of Kunming Medical University (CXTD202209), Yunnan Provincial Endocrinology and Metabolism Clinical Medicine Center (YWLCYXZXXYS20221005),Clinical Collaboration Project of Traditional Chinese and Western Medicine for Major Difficult Diseases of Yunnan Province (300073)

6 However, the underlying mechanisms for DMARDs are not fully understood, recent studies reported that DMARDs can initiate multiple signaling pathways improving RA

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These symptoms may include dizziness, difficulty walking normally, nervousness, anxiety, weakness, and uncoordinated movements

Recent advances in three dimensional (3D) printing 56 and rapid prototyping now allow researchers to produce anatomic 3D tissue engineered constructs