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Description
The pathological significance of this mode of PFK-1 regulation is that the targeting of the enzyme for inhibition of the O -GlcNAcylation has been shown to inhibit cancer growth and impairs tumor formation
Interestingly, the NCT00071799 study reported that MDS patients treated with 5-Aza (75 mg/m 2 subcutaneously) + BSC exhibited prolonged hematological responses and increased RBC IT compared to those receiving standard chemotherapy (cytarabine + anthracycline) + BSC (median OS: 24.5 months vs 16 months) [346,347,348,349,350]
Wei, Green synthesis of carbon dots from rose-heart radish and application for Fe 3+ detection and cell imaging
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Front Pharmacol (2021) 12:824180
A.M., T.W., and N.P.D.-D
