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Add each solvent one by one: 10% DMSO 90% (20% SBE--CD in Saline) Solubility: 2 mg/mL (3.09 mM)

Exercise and Physical Performance Research Age-Related Physical Decline Investigations in aging mice demonstrated that MOTS-c treatment significantly improved physical capacity across multiple age groups: Enhanced running endurance in young (2-month), middle-aged (12-month), and old (22-month) mice Improved grip strength and rotarod performance in aged animals Late-life intermittent treatment (beginning at 23.5 months) increased healthspan metrics Reversal of age-dependent decline in mitochondrial function Notably, human studies confirmed that exercise induces endogenous MOTS-c expression in both skeletal muscle tissue and circulation, suggesting evolutionary conservation of exercise-responsive signaling

4 GGG specifically inhibits migration of P2RY8-expressing WEHI-231 cells

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Funding The UMR1136 is supported by a grant overseen by the French National Research Agency (ANR) as part of the Investissements dAvenir program (ANR-11-LABX-0002-01, Lab of Excellence ARBRE)