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Importantly, the ablation of p21, a key mediator of senescence, in Fh1-deficient mice resulted in the transformation of benign renal cysts into a hyperplastic lesion, suggesting that fumarate-induced senescence needs to be bypassed for the initiation of renal cancers

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Functions and Importance of Vitamin B12 Vitamin B12 is integral to maintaining healthy nerve cells and producing DNA, the genetic material in all cells

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