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While the non-infectious forms can be linked to arteritis of the large vessels, the infectious forms are a rare but fearful complication of infective endocarditis

Through extensive structure-activity studies, we have demonstrated that a physical mixture of a cyclic decapeptide, toll-like receptor 2 (TLR-2) targeting lipid peptide and GAS B cell epitope (J8) chemically-conjugated to a universal T helper cell epitope (PADRE) produced significant IgG antibodies when administered subcutaneously to mice with strong opsonisation potential against clinical GAS 9,10,11

[DOI] [PubMed] [Google Scholar] 46.Wozniak AL, Griffin S, Rowlands D, Harris M, Yi M, Lemon SM, Weinman SA

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