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These nuclear respiratory factors are primarily tasked with governing the expression of mitochondrial respiratory genes (proteins), key mitochondrial enzyme transcription, coding genes for mitochondrial respiratory complex subunits, mitochondrial translation components, and heme biosynthase (Kiyama et al., 2022

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The MHRA recommends considering periodic B12 monitoring in patients on metformin who have risk factors for deficiency, and testing if symptoms develop

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