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Blood mtDNA copy number (mtDNA-cn) is elevated and linked to depression via polygenic risk scores [33,34,35,36,37], with alterations observed as early as adolescent depression [38, 39]

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Collectively, the results presented here indicate that the cellular recycling mechanism of autophagy is required for the beneficial effects of hormetic heat stress and of HSF-1 overexpression on stress resistance, longevity and proteostasis

In this chapter, we provide an overview on recent advances in antiviral therapies against HCV and highlight the most important host factors explored as therapeutic targets

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