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The Kolonin mouse study that started everything In 2004, Mikhail Kolonin and colleagues published a landmark study in Nature Medicine titled "Reversal of obesity by targeted ablation of adipose tissue." This was the paper that introduced the world to vascular-targeted fat destruction

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Tissue-related signaling pathways

The riskbenefit assessment for wellness or anti-aging interventions may differ substantially from that applied to disease-specific therapeutic indications, given the differing clinical objectives and risk tolerances

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